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Faculty Directory


Sophie Sokolow, Ph.D., Mpharm
Assistant Professor

Location: 5-946 Factor Building
Phone: (310) 206-3390
Fax: (310) 206-3241
E-mail: ssokolow@sonnet.ucla.edu

Faculty Research and Clinical Expertise

Research: Calcium signaling pathways involved in the pathogenesis of Alzheimer's disease. Special focus on the identification of novel targets for pharmacological intervention in Alzheimer's Disease.
Clinical: Pharmacist, pharmacovigilance and pharmacosurveillance.

Courses

N295A, N225A, N115 (W11), N225B (Sp11), N204

Professional Activities

1994 - 2004 Member, National Board of Pharmacy, Belgium 
1997 - 2004 Consultant, Belgian Ministry of Public Health, Center of Drug Monitoring, Brussels, Belgium.
2003 -   Member, Biophysical Society
2004 -  Remote reviewer, Journal of Clinical Investigation
2004 -   Remote reviewer, European Commission, Brussels, Belgium.
2005 -   International Doping Control Officer, International Doping Tests & Management (IDTM)
2007 -   Member, Society for Neuroscience (SfN) 
2009 Member, Alzheimer's Association International Society to Advance Alzheimer Research and Treatment (ISTAART)
2009  -    Member, Faculty for Undergraduate Neuroscience (FUN)
2009 -   Alzheimer's association peer reviewer

Education

University of Mons-Hainaut, Mons, Belgium, BSc, 1991, Pharmaceutical Sciences
Free University of Brussels, Belgium, MSc, 1994, Pharmacy
Free University of Brussels, Belgium, MSc, 2003, Health Sciences - Pharmaceutical Sciences
Free University of Brussels, Belgium, PhD, 2004, Biomedical Sciences

Honors and Awards

1991 Awarded as the most Promising Student in the B. Sc. Program in Pharmaceutical Sciences, University of Mons-Hainaut, Belgium.
1994 Upjohn Award for the Most Promising Student in the M. Sc. program of Pharmacy degree, Free University of Brussels, School of Pharmacy, Belgium.
1997 Doctorate Fellowship in recognition of the undergraduate outstanding merit, Free University of Brussels, Research committee, Belgium
2003 Fellowship award, International Federation of Clinical Neurophysiology (IFCN), San Francisco, CA, USA.
2009 Travel award, Alzheimer's Association, International Conference on Alzheimer's disease, Vienna, Austria.

Publications

Sokolow S, Henkins KM, Williams IA, Vinters HV, Schmid I, Cole GM, Gylys KH. (2012).Isolation of synaptic terminals from Alzheimer's disease cortex. Cytometry A., 81, 248-54.

Ringman JM, Schulman H, Becker C, Jones T, Bai Y, Immermann F, Cole G, Sokolow S, Gylys K, Geschwind DH, Cummings JL, Wan HI. (2012). Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations. Archives of Neurology, 69, 96-104.

Sokolow S, Luu SH, Nandy K, Miller CA, Vinters HV, Poon WW, Gylys KH. (2012). Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex. Neurobiology of Disease, 45, 381-7.

A. Verwey, W. M. Van der Flier, K. Blennow, C. Clark, S. Sokolow, P. P. De Deyn, D. Galasko, H.J. Hampel, T. Hartmann, E. Kapaki, L. Lannfelt, P. D. Mehta, L. Parnetti, A. Petzold, T. Pirttila, L. Saleh, A. Skinningsrud, J. Van Swieten, M. M. Verbeek, J. Wiltfang, S. G. Younkin, P. Scheltens, and R. A. Blankenstein. A worldwide multicenter comparison of assays for CSF biomarkers in Alzheimer disease. Ann Clin Biochem.; 46(Pt 3):235-40, 2009.

L. Cross, B. P. Meloni, A. J. Bakker, S. Sokolow, A.Herchuelz, S. Schurmans, N. W. Knuckey. Neuronal injury in NCX3 knockout mice following permanent focal cerebral ischemia and in NCX3 knockout cortical neuronal cultures following oxygen-glucose deprivation and glutamate exposure (2009). J Exp Stroke Transl Med 2(1): 3-9.

J. Jeffs, B. P. Meloni, S. Sokolow, A. Herschuelz, S. Schurmans and N. W. Knuckey (2008). NCX3 knockout mice exhibit increased hippocampal CA1 and CA2 neuronal damage compared to wild-type mice following global cerebral ischemia. Exp Neurol. 210 (1), 268-273.

M. Ringman, S. G. Younkin, D. Pratico, W. Seltzer, G. M. Cole, D. H. Geschwind, Y. Rodriguez, B. Schaffer, J. Fein, S. Sokolow, E. R. Rosario, K. H. Gylys, A. Varpetian, L. D. Medina, J.L. Cummings (2008). Biochemical Markers in Persons with Pre-Clinical Familial Alzheimer's Disease. Neurology. 8;71(2):85-92

Fein, S. Sokolow, C. A. Miller, H. V. Vinters, F. Yang, G. M. Cole, K. H. Gylys (2008). Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes. Am. J. Pathol. 172(6):1683-92.

Molinaro, O. Cuomo, G. Pignataro, F. Boscia, R. Sirabella, A. Pannaccione, A. Secondo, A. Scorziello, A. Adornetto, R. Gala, S. Sokolow, A. Herchuelz, S. Schurmans, G. Di Renzo, L. Annunziato (2008). Targeted Disruption of Na+/Ca2+ Exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage. J. Neurosci. 28(5), 1179-84.

Wehling-Henricks*, S. Sokolow*, J. J. Lee, K. H. Myung, A. Villalta and J. G. Tidball (2008). Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy. Hum. Mol. Genet. 17(15):2280-92.* Authors contributing equally to the investigation.

P Philippeau, M. Manto, S. Sokolow, M. A. Laute J. P Brion, M. Pandolfo and R. Pochet (2005). Recent advances in transgenic models of ALS - Electrophysiological, morphological and neurochemical characterization of hSOD-1 G93A transgenic rats. Recent Research in Developmental Physiology, 3:13-31.


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