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Faculty Directory


Paul M. Macey, Ph.D.
Associate Dean for Information Technology and Innovations

Location: 3-246 Factor Building
Phone: (310) 825-3308
E-mail: pmacey@ucla.edu

Faculty Research and Clinical Expertise

Research: I study the brain in people with sleep disordered breathing. I seek to help understand how the neural regulation of body functions such breathing and cardiovascular control, and of psychological factors such as depression and anxiety are affected in people with obstructive sleep apnea. Our group typically uses brain MRI scanning to look at brain structure and function, and we relate brain changes to performance on physiologic tests of blood pressure and breathing, as well as measurements of mood and cognitive capacity. As well as adults with obstructive sleep apnea, I am part of a team looking at similar questions in heart failure, and in the pediatric condition of congenital central hypoventilation syndrome. I also regularly collaborate with faculty outside UCLA on a variety of brain imaging projects.

Courses

N173

Education

University of Canterbury, New Zealand, BE (hons.), 1991, Electrical Engineering
University of Canterbury, New Zealand, PhD, 1998, Electrical Engineering

Publications

Kumar R, Woo MS, Macey PM, Woo MA, Harper RM. (2012). Progressive gray matter changes in patients with congenital central hypoventilation syndrome. Pediatric Research, 71, 701-6.

Macey PM, Wu P, Kumar R, Ogren JA, Richardson HL, Woo MA, Harper RM.(2012).Differential responses of the insular cortex gyri to autonomic challenges.Autonomic Neuroscience: basic & clinical, 168, 72-81.

Kumar R, Delshad S, Woo MA, Macey PM, Harper RM. (2012). Age-related regional brain T2-relaxation changes in healthy adults. Journal of Magnetic Resonance Imaging, 35, 300-308.

Kumar R, Nguyen HD, Macey PM, Woo MA, Harper RM.(2012).Regional brain axial and radial diffusivity changes during development. Journal of Neuroscience, 90, 346-55.

Macey PM. (2012). Is brain injury in obstructive sleep apnea reversible? Sleep, 35, 9-10.

Cross RL, Kumar R, Macey PM, Doering LV, Alger JR, Yan-Go Fl, Harper RM.
Neural alterations and depressive symptoms in obstructive sleep apnea patients. Sleep. 31: 1103-9.

Wrigley PJ, Gustin SM, Macey PM, Nash PG, Gandevia SC, Macefield VG, Siddall PJ. Anatomical changes in human motor cortex and motor pathways following complete thoracic spinal cord injury. Cereb Cortex 2008 (Epub ahead of print)

Kumar R, Birrer BV, Macey PM, Woo MA, Gupta RK, Yan-Go FL, Harper RM.
Reduced mammillary body volume in patients with obstructive sleep apnea. Neurosci Lett 2008; 438: 330-334.

Kumar R, Macey PM, Woo MA, Alger JR, Harper RM. Diffusion tensor imaging
demonstrates brainstem and cerebellar abnormalities in congenital central
hypoventilation syndrome. Pediatr Res 2008; 64: 275-280.

Serber SL, Kumar R, Woo MA, Macey PM, Fonarow GC, Harper RM. Cognitive test performance and brain pathology. Nursing Research 2008; 57: 75-83.

Macey PM, Woo MA, Harper RM. Hyperoxic brain effects are normalized by addition of CO2. PLOS Medicine 2007; 4: 1-8.

Woo MA, Macey PM, Keens PT, Kumar R, Fonarow GC, Hamilton MA, Harper RM. Aberrant central nervous system responses to the Valsalva maneuver in heart failure. Congestive Heart Failure 2007;13:29-35.

Henderson LA, Macey KE, Macey PM, Woo MA, Yan-Go FL, Harper RM. Regional brain response patterns to Cheyne-Stokes breathing. Resp Physiol Neurobiol 2006: 150:87-93

Kumar R, Macey PM, Woo MA, Alger JR, Harper RM. Elevated mean diffusivity in widespread brain regions in congenital central hypoventilation syndrome. J Magnetic Resonance Imaging 2006; 24: 1252-1258

Macey KE, Macey PM, Woo MA, Henderson LA, Frysinger RC, Harper RK, Alger JR, Yan-Go F, Harper RM. Inspiratory loading elicits aberrant fMRI signal changes in obstructive sleep apnea. Respir Physiol Neurobiol 2006; 151: 44-60.

Harper RM, Macey PM, Woo MA, Macey KE, Keens TG, Gozal D, Alger JR.
Hypercapnic exposure in congenital central hypoventilation syndrome reveals CNS
respiratory control mechanisms. J Neurophysiol 2005; 93: 1647-1658.

Kumar R, Macey P, Woo, M, Alger J, Keens T, Harper R. Neuroanatomic deficits in congenital central hypoventilation syndrome. J Comparative Neurol 2005, 487: 361-371

Macey PM, Macey KE, Woo MA, Keens TG, Harper RM. Aberrant neural responses tocold pressor challenges in congenital central hypoventilation syndrome. Pediatric Research 2005; 57: 1-9.

Macey PM, Harper RM. OSA brain morphology differences: magnitude of loss
approximates age-related effects. Am J Repir Crit Care Med 2005; 172: 1956-7.

Woo MA, Macey PM, Keens PT, Kumar R, Fonarow GC, Hamilton MA, Harper RM. Functional abnormalities in brain areas which mediate autonomic nervous system control in advanced heart failure. J Cardiac Failure 2005; 11:437-446.

Woo MA, Macey PM, Macey KE, Keens TG, Woo MS, Harper RK, Harper RM. FMRI responses to hyperoxia in congenital central hypoventilation syndrome. Pediatric Research 2005; 57: 1-10


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